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The article considers technical solutions to improve the quality of life support system in long-distance passenger trains (PVPDS), in particular in the water supply and ventilation systems, which ensure safe and comfortable passenger travel conditions. The quality of water in the coach is determined by the conditions of initial water filling at the intermediate stations, which can be adversely affected by the sanitary condition of the storage tank. Currently filters are installed in the ventilation system, efficiency of which is questionable in pandemic conditions. Scientific works and elaborations of native and foreign scientists, up-to-date concepts of organizing comfortable conditions in the PVPDS, as well as methodical and normative-reference materials on the given theme were used when writing the article. The effectiveness of the proposed method was confirmed in the course of experimental research, the results of which were used in the implementation of the investment project "Clean Water" of JSC "Russian Railways". Technical solutions have been proposed to improve the quality of life support systems using ozonization technology. Their realization will allow the life support system to operate in the water purification and disinfection mode and sterilization the air environment in the PVPDS. The condition for the efficient use is the availability of compressed air for the ejector operation in the mode of supplying the ozone-air mixture required for water and air cleaning and disinfection in the car. Ozonization is performed separately in the automatic mode. The ozone method for solving the problems of life support in coach cars is a perspective direction consider its generality and, therefore, ability of using it on the infrastructure objects for disinfection and sterilization of premises, reserved volumes and production capacities.